Landscape of somatic mutations in aging human heart muscle cells

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Nature Aging | 2022年 / 2卷
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Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.
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页码：686 / 687
页数：1
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