Drug repurposing: progress, challenges and recommendations

被引：0

作者：

Sudeep Pushpakom

Francesco Iorio

Patrick A. Eyers

K. Jane Escott

Shirley Hopper

Andrew Wells

Andrew Doig

Tim Guilliams

Joanna Latimer

Christine McNamee

Alan Norris

Philippe Sanseau

David Cavalla

Munir Pirmohamed

机构：

[1] MRC Centre for Drug Safety Science,Department of Molecular and Clinical Pharmacology

[2] University of Liverpool,Department of Biochemistry

[3] Wellcome Sanger Institute,Licensing Division

[4] Institute of Integrative Biology,Manchester Institute of Biotechnology and Department of Chemistry

[5] University of Liverpool,undefined

[6] Emerging Innovations Unit,undefined

[7] Scientific Partnering and Alliances,undefined

[8] IMED Biotech Unit,undefined

[9] Medicines and Healthcare Products Regulatory Agency (MHRA),undefined

[10] Harrison Goddard Foote,undefined

[11] Patent and Trademark Attorneys,undefined

[12] Faculty of Science and Engineering,undefined

[13] The University of Manchester,undefined

[14] Healx Ltd.,undefined

[15] St John's Innovation Centre,undefined

[16] Medical Research Council,undefined

[17] Medicines Research Centre,undefined

[18] Target Sciences,undefined

[19] GlaxoSmithKline R&D,undefined

[20] Numedicus Ltd,undefined

来源：

Nature Reviews Drug Discovery | 2019年 / 18卷 / 1期

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Drug repurposing — a strategy for identifying new uses for approved or investigational drugs that are outside the scope of the original medical indication — has the potential for greater success rates and reduced costs compared with developing entirely new drugs. Pirmohamed and colleagues present approaches used for drug repurposing, discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed.

引用

页码：41 / 58

页数：17

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