Synthesis of ivermectin-4″,5-diyl[bis(N-methylcarbamate)]

被引：0
|
作者：
A. N. Blinnikov
E. I. Chernoburova
N. G. Kolotyrkina
M. A. Shchetinina
V. A. Lishchuk
K. L. Ovchinnikov
A. V. Kolobov
M. Kh. Dzhafarov
F. I. Vasilevich
I. V. Zavarzin
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology,undefined
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
avermectin B; ivermectin; methyl isocyanate; MoO; Cl; (DMF); catalyst; ivermectin-4″,5-diyl[bis(; -methylcarbamate)]; antiparasitic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New ivermectin-4″,5-diyl[bis(N-methylcarbamate)] was synthesized by the MoO2Cl2(DMF)2-catalyzed reaction of ivermectin with methyl isocyanate. The synthesized compound could find application as antiparasitic agent.
引用
收藏
页码：833 / 835
页数：2
相关论文
共 50 条
  • [1] Synthesis of ivermectin-4aEuro3,5-diyl[bis(N-methylcarbamate)]
    Blinnikov, A. N.
    Chernoburova, E. I.
    Kolotyrkina, N. G.
    Shchetinina, M. A.
    Lishchuk, V. A.
    Ovchinnikov, K. L.
    Kolobov, A. V.
    Dzhafarov, M. Kh.
    Vasilevich, F. I.
    Zavarzin, I. V.
    RUSSIAN CHEMICAL BULLETIN, 2018, 67 (05) : 833 - 835
  • [2] IN-VITRO AND IN-VIVO HYDROLYSIS OF SALICYLANILIDE N-METHYLCARBAMATE AND 4-BIPHENYLYL N-METHYLCARBAMATE
    BROWN, LW
    FORIST, AA
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (06) : 850 - &
  • [3] ANALOGS OF 2,6-PYRIDINEDIMETHANOL BIS(N-METHYLCARBAMATE)
    JUBY, PF
    BABEL, RB
    BOCIAN, GE
    CLADEL, NM
    GODFREY, JC
    HALL, BA
    HUDYMA, TW
    LUKE, GM
    MATISKEL.JD
    MINOR, WF
    MONTZKA, TA
    PARTYKA, RA
    STANDRID.RT
    CHENEY, LC
    JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (03) : 491 - &
  • [4] MICROBIAL-METABOLISM OF N-METHYLCARBAMATE INSECTICIDE .2. SYNTHESIS OF METABOLITES OF O-SEC-BUTYLPHENYL N-METHYLCARBAMATE
    SUZUKI, T
    TAKEDA, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1976, 24 (09) : 1976 - 1982
  • [5] GAS CHROMATOGRAPHIC DETERMINATION OF 4-BENZOTHIENYL N-METHYLCARBAMATE
    EPSTEIN, AJ
    GASKILL, DR
    LUCCHESI, CA
    ANALYTICAL CHEMISTRY, 1967, 39 (07) : 721 - &
  • [6] METHODS FOR DETERMINATION OF MOBAM (4-BENZOTHIENYL N-METHYLCARBAMATE)
    CHASAR, AG
    LUCCHESI, CA
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1967, 15 (06) : 1030 - &
  • [7] MICROBIAL-METABOLISM OF N-METHYLCARBAMATE INSECTICIDE .4. NEW METABOLITES OF O-SEC-BUTYLPHENYL N-METHYLCARBAMATE BY CLADOSPORIUM-CLADOSPORIOIDES
    SUZUKI, T
    TAKEDA, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1976, 24 (09) : 1988 - 1991
  • [8] Hapten synthesis and production of monoclonal antibodies to the N-methylcarbamate pesticide methiocarb
    Abad, A
    Moreno, MJ
    Montoya, A
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (06) : 2417 - 2426
  • [9] 4-nitrophenyl N-(2-isopropylthiazol-4-ylmethyl)-N-methylcarbamate
    Xu, Hao
    Wang, Peng
    Huang, Wen-Long
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O149 - U3845
  • [10] SOME PHARMACOLOGICAL ACTIVITIES OF 2,6-BIS-(HYDROXYMETHYL)PYRIDIN-BIS-(N-METHYLCARBAMATE) (PYRIDINOLCARBAMATE)
    MANTOVANI, P
    IMPICCIATORE, M
    FARMACO-EDIZIONE SCIENTIFICA, 1970, 25 (12): : 912 - +
12345