Design, Synthesis, In Vitro Cytotoxicity, ADME Prediction, and Molecular Docking Study of Benzimidazole-Linked Pyrrolone and N-Benzylpyrrolone Derivatives

被引：0
|
作者：
A. Husain
M. Bhutani
S. Parveen
S. A. Khan
A. Ahmad
M. A. Iqbal
机构：
[1] Department of Pharmaceutical Chemistry,
[2] School of Pharmaceutical Education and Research,undefined
[3] Jamia Hamdard,undefined
[4] Chemistry Department,undefined
[5] Faculty of Science,undefined
[6] Taibah University,undefined
[7] Yanbu Branch,undefined
[8] Department of Chemistry,undefined
[9] School of Chemical and Life Sciences,undefined
[10] Jamia Hamdard,undefined
[11] College of Pharmacy,undefined
[12] National University of Science and Technology,undefined
[13] Health Information Technology Department,undefined
[14] Faculty of Applied Studies,undefined
[15] King Abdulaziz University,undefined
来源：
Russian Journal of Organic Chemistry | 2022年 / 58卷
关键词：
heterocyclics; pyrrolone; anticancer activity; VEGFR-2; molecular docking;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1438 / 1450
页数：12
相关论文
共 50 条
  • [1] Design, Synthesis, In Vitro Cytotoxicity, ADME Prediction, and Molecular Docking Study of Benzimidazole-Linked Pyrrolone and N-Benzylpyrrolone Derivatives
    Husain, A.
    Bhutani, M.
    Parveen, S.
    Khan, S. A.
    Ahmad, A.
    Iqbal, M. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (10) : 1438 - 1450
  • [2] Synthesis, in vitro cytotoxicity,ADME,and molecular docking studies of benzimidazole-bearing furanone derivatives
    Husain, Asif
    Bhutani, Medha
    Parveen, Shazia
    Khan, Shah Alam
    Ahmad, Aftab
    Iqbal, Md Azhar
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2021, 68 (02) : 362 - 373
  • [3] Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents
    Meryem Erol
    Ismail Celik
    Ozlem Temiz-Arpaci
    Hakan Goker
    Fatma Kaynak-Onurdag
    Suzan Okten
    Medicinal Chemistry Research, 2020, 29 : 2028 - 2038
  • [4] Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents
    Erol, Meryem
    Celik, Ismail
    Temiz-Arpaci, Ozlem
    Goker, Hakan
    Kaynak-Onurdag, Fatma
    Okten, Suzan
    MEDICINAL CHEMISTRY RESEARCH, 2020, 29 (11) : 2028 - 2038
  • [5] Design, Synthesis, in Vitro and in Silico Studies of Benzimidazole-Linked Oxadiazole Derivatives as Anti-inflammatory Agents
    Celik, Ismail
    Sarialtin, Sezen Yilmaz
    Coban, Tulay
    Kilcigil, Gulgun
    CHEMISTRYSELECT, 2022, 7 (28):
  • [6] In vitro α-Glucosidase Inhibition, Cytotoxicity, SAR, Swiss ADME Prediction and Molecular Docking Study of New N-Substituted Hydantoin Derivatives
    Tshiluka, Ndivhuwo R.
    Mbedzi, Dakalo T.
    Bvumbi, Mpelegeng V.
    Mnyakeni-Moleele, Simon S.
    CHEMISTRYOPEN, 2025,
  • [7] Furanone-functionalized benzothiazole derivatives: synthesis, in vitro cytotoxicity, ADME, and molecular docking studies
    Husain, Asif
    Bedi, Silky
    Parveen, Shazia
    Khan, Shah Alam
    Ahmad, Aftab
    Iqbal, Md Azhar
    Farooq, Aasif
    Ahmed, Anwar
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2022, 77 (01): : 41 - 53
  • [8] Design, Docking and ADME Study of Benzimidazole Derivatives as Potential Antibacterial Agents
    Alfahad, Mohanad
    Ismael, Sarah S.
    Jasim, Mahmood H. M.
    Alassaf, Fawaz A.
    Qazzaz, Mohannad E.
    Abed, Mohammed N.
    LATIN AMERICAN JOURNAL OF PHARMACY, 2021, 40 (12): : 2914 - 2919
  • [9] In Vitro Cytotoxicity and Aromatase Inhibitory Activity of Flavonoids: Synthesis, Molecular Docking and In silico ADME Prediction
    Shah, Umang
    Patel, Samir
    Patel, Mehul
    Jain, Neeraj
    Pandey, Nilesh
    Chauhan, Alex
    Patel, Ashish
    Patel, Sandip
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2022, 22 (07) : 1370 - 1385
  • [10] Design, synthesis, molecular docking, and ADME prediction evaluation of phenyloxazole derivatives as α-glucosidase inhibitors
    Fan, Meiyan
    Yang, Wei
    Peng, Zhiyun
    Wang, Guangcheng
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1292
12345