Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

被引：5

作者：

Sugino N. ^{[1
,2
]}

Ichinohe T. ^{[3
]}

Takaori-Kondo A. ^{[2
]}

Maekawa T. ^{[1
]}

Miura Y. ^{[1
]}

机构：

[1] Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto

[2] Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto

[3] Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima

来源：

Inflammation and Regeneration | / 37卷 / 1期

基金：

日本学术振兴会;

关键词：

Cell therapy; Hematopoiesis; Immunomodulation; Mesenchymal stromal/stem cell; Pharmacological modification; Regeneration;

D O I：

10.1186/s41232-017-0038-5

中图分类号：

学科分类号：

摘要：

The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies. © 2017 The Author(s).

引用

共 50 条

[21] DIRECT COMPARISON OF WHARTON'S JELLY AND BONE MARROW MESENCHYMAL STEM/STROMAL CELLS
Batsali, A.
Pontikoglou, C. G.
Kouvidi, E.
Damianaki, A.
Kastrinaki, M.
Papadaki, H. A.
CYTOTHERAPY, 2014, 16 (04) : S73 - S74
[22] Effects of Irradiation on the Functional Characteristics of Human Bone Marrow Mesenchymal Stromal/Stem Cells
Iwasa, Masaki
Miura, Yasuo
Fujishiro, Aya
Tamura, Akihiro
Sato, Atsushi
Yokota, Asumi
Nakagawa, Yoko
Yoshioka, Satoshi
Hirai, Hideyo
Andoh, Akira
Ichinohe, Tatsuo
Maekawa, Taira
BLOOD, 2014, 124 (21)
[23] Marrow stem cells, mesenchymal progenitor cells, and stromal progeny
La Russa, VF
Schwarzenberger, P
Miller, A
Agrawal, K
Kolls, J
Weiner, R
CANCER INVESTIGATION, 2002, 20 (01) : 110 - 123
[24] Transplantation of bone marrow stromal mesenchymal cells in the treatment of acute myocardial infarction
Borsani, Paolo
Marazzi, Raffaella
Passi, Alberto
Mariscalco, Giovanni
Vigetti, Davide
Salerno-Uriarte, Jorge A.
Sala, Andrea
ARCHIVES OF MEDICAL SCIENCE, 2009, 5 (02) : 156 - 162
[25] Phenotypic and Functional Equivalency of Digested Bone Marrow Mesenchymal Stem Cells to Aspirated Bone Marrow Mesenchymal Stem Cells
Miller, Hannah Marie
Gu, Dongsheng
Johnstone, Brian
Sherry, Aubrey
LaFontaine, Michael
Woods, Erik
FASEB JOURNAL, 2019, 33
[26] TREATMENT OF BONE MARROW HYPOPLASIA WITH MESENCHYMAL STEM CELLS - CASE REPORT
Amorim, V. M.
Junior, C. A. C.
Brunel, H. S. S.
Malard, P. F.
CYTOTHERAPY, 2021, 23 (04) : 36 - 36
[27] USE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF BONE MARROW APLASIA IN DOGS
Alvarenga, M. L.
Barberini, D. J.
Maciel, A. P.
Landim-Alvarenga, F. C.
CYTOTHERAPY, 2021, 23 (04) : 38 - 38
[28] Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury
Zou, Xiong-Fei
Zhang, Bao-Zhong
Qian, Wen-Wei
Cheng, Florence Mei
WORLD JOURNAL OF STEM CELLS, 2024, 16 (08):
[29] Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells (BM-MSCS) from patients with hematological disorders: Correlation with culture conditions and bone marrow microenvironment.
Campioni, D.
Moretti, S.
Ferrari, L.
Dominici, M.
Lanza, F.
CYTOTHERAPY, 2006, 8
[30] The extracellular matrix produced by bone marrow stromal cells forms a niche for mesenchymal stem cells.
Chen, X.
DeLoose, A.
Mommsen, L.
Dusevich, V.
Feng, J.
Manolagas, S. C.
Jilka, R. L.
JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S390 - S390

← 1 2 3 4 5 →