Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

被引：5
|
作者：
Sugino N. [1 ,2 ]
Ichinohe T. [3 ]
Takaori-Kondo A. [2 ]
Maekawa T. [1 ]
Miura Y. [1 ]
机构：
[1] Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto
[2] Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto
[3] Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima
来源：
Inflammation and Regeneration | / 37卷 / 1期
基金：
日本学术振兴会;
关键词：
Cell therapy; Hematopoiesis; Immunomodulation; Mesenchymal stromal/stem cell; Pharmacological modification; Regeneration;
D O I：
10.1186/s41232-017-0038-5
中图分类号：
学科分类号：
摘要：
The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies. © 2017 The Author(s).
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