CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

被引：0

作者：

Deanna L Wallace

Ming-Hu Han

Danielle L Graham

Thomas A Green

Vincent Vialou

Sergio D Iñiguez

Jun-Li Cao

Anne Kirk

Sumana Chakravarty

Arvind Kumar

Vaishnav Krishnan

Rachael L Neve

Don C Cooper

Carlos A Bolaños

Michel Barrot

Colleen A McClung

Eric J Nestler

机构：

[1] University of Texas Southwestern Medical Center,Departments of Psychiatry and Neuroscience

[2] 5323 Harry Hines Boulevard,Fishberg Department of Neuroscience

[3] Mount Sinai School of Medicine,Department of Psychology

[4] One Gustav L. Levy Place Box 1065,Department of Psychiatry

[5] Florida State University,undefined

[6] Harvard Medical School,undefined

[7] McLean Hospital,undefined

[8] Institut des Neurosciences Cellulaires et Intégratives,undefined

[9] UMR7168,undefined

[10] CNRS and University Louis Pasteur,undefined

[11] 21 Rue Descartes,undefined

[12] Present addresses: Helen Willis Neuroscience Institute,undefined

[13] University of California Berkeley,undefined

[14] 132 Barker Hall,undefined

[15] Berkeley,undefined

[16] California 94720,undefined

[17] USA (D.L.W.),undefined

[18] Merck Laboratories,undefined

[19] 33 Avenue Louis Pasteur,undefined

[20] Boston,undefined

[21] Massachusetts 02115,undefined

[22] USA (D.L.G.),undefined

[23] and Department of Pharmacology and Toxicology,undefined

[24] Virginia Commonwealth University,undefined

[25] 1112 East Clay Street,undefined

[26] Richmond,undefined

[27] Virginia 23298,undefined

[28] USA (T.A.G.).,undefined

来源：

Nature Neuroscience | 2009年 / 12卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

cAMP response element–binding protein (CREB) is a key regulator of the nucleus accumbens shell function in animals' responses to emotional stimuli. The present study demonstrates that passive stress in the form of social isolation induces anhedonia and depression-like symptoms that are mediated by CREB activity and neuronal excitability.

引用

页码：200 / 209

页数：9

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