Disentangling extrachromosomal circular DNA heterogeneity in single cells with scEC&T-seq

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Nature Genetics | 2023年 / 55卷
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We introduce scEC&T-seq, a new single-cell sequencing method that enables parallel profiling of extrachromosomal circular DNA and mRNAs in single cells. Using scEC&T-seq, we characterized all types of circular DNA elements in single human cancer cells and profiled the intercellular heterogeneity and structural dynamics of cancer-specific extrachromosomal DNA.
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页码：740 / 741
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