This study shows that Qsp1 is an autoregulatory signalling peptide that matures extracellularly and is imported into the cell by Opt1 to regulate virulence. This is the first description of the molecular mechanisms that are involved in eukaryotic quorum sensing.
机构:
Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Byeon, Jae-Young
Sim, Jun
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Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Sim, Jun
Ryu, Eun-Ju
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Seoul Natl Univ, Sch Dent, Dept Oral Microbiol & Immunol, Seoul 03080, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Ryu, Eun-Ju
Sim, Jaehyun
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Seoul Natl Univ, Sch Dent, Dept Oral Microbiol & Immunol, Seoul 03080, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Sim, Jaehyun
Lee, Hwan
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Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Lee, Hwan
Cho, Kwang-Hwi
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Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
Cho, Kwang-Hwi
Choi, Bong-Kyu
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Seoul Natl Univ, Sch Dent, Dept Oral Microbiol & Immunol, Seoul 03080, South KoreaSoongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea
机构:
NYU, Ctr Comparat Funct Genom, New York, NY 10003 USA
Courant Inst Math Sci, New York, NY 10012 USA
Inst Syst Biol, Seattle, WA 98103 USANYU, Ctr Comparat Funct Genom, New York, NY 10003 USA