Age at first birth in women is genetically associated with increased risk of schizophrenia

被引:0
|
作者
Guiyan Ni
Jacob Gratten
Naomi R. Wray
Sang Hong Lee
机构
[1] University of South Australia,Australian Center for Precision Health, University of South Australia Cancer Research Institute
[2] University of New England,School of Environmental and Rural Science
[3] University of Queensland,Institute for Molecular Bioscience
[4] University of Queensland,Queensland Brain Institute
[5] Massachusetts General Hospital,Analytic and Translational Genetics Unit
[6] Broad Institute of MIT and Harvard,Stanley Center for Psychiatric Research
[7] Broad Institute of MIT and Harvard,Medical and Population Genetics Program
[8] Massachusetts General Hospital,Psychiatric and Neurodevelopmental Genetics Unit
[9] Trinity College Dublin,Neuropsychiatric Genetics Research Group, Department of Psychiatry
[10] Cardiff University,MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine
[11] Cardiff University,National Centre for Mental Health
[12] Erl Wood Manor,Eli Lilly and Company Limited
[13] King’s College London,Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry
[14] Technical University of Denmark,Center for Biological Sequence Analysis, Department of Systems Biology
[15] Boston Children’s Hospital,Division of Endocrinology and Center for Basic and Translational Obesity Research
[16] Boston,Department of Clinical Neuroscience, Psychiatry Section
[17] Karolinska Institutet,Department of Psychiatry
[18] Diakonhjemmet Hospital,NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine
[19] University of Oslo,Centre for Integrative Register
[20] Aarhus University,based Research, CIRRAU
[21] AarhusUniversity,National Centre for Register
[22] iPSYCH,based Research
[23] State Mental Hospital,The Lundbeck Foundation Initiative for Integrative Psychiatric Research
[24] Stanford University,Department of Psychiatry and Behavioral Sciences
[25] Atlanta Veterans Affairs Medical Center,Department of Psychiatry and Behavioral Sciences
[26] Emory University,Department of Psychiatry and Behavioral Sciences
[27] Virginia Commonwealth University,Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
[28] Max Planck Institute of Experimental Medicine,Clinical Neuroscience
[29] University of Pécs,Department of Medical Genetics
[30] University of Pécs,Szentagothai Research Center
[31] Karolinska Institutet,Department of Medical Epidemiology and Biostatistics
[32] University of Iowa Carver College of Medicine,Department of Psychiatry
[33] University Medical Center Groningen,School of Nursing
[34] Department of Psychiatry,Athinoula A Martinos Center
[35] University of Groningen,Center for Brain Science
[36] Louisiana State University Health Sciences Center,Department of Psychiatry
[37] Massachusetts General Hospital,Department of Psychiatry
[38] Harvard University,Department of Human Genetics
[39] Massachusetts General Hospital,Department of Psychiatry
[40] University of California at San Francisco,Department of Human Genetics, David Geffen School of Medicine
[41] University Medical Center Utrecht,School of Psychiatry
[42] Department of Psychiatry,Royal Brisbane and Women’s Hospital
[43] Rudolf Magnus Institute of Neuroscience,Institute of Psychology
[44] Icahn School of Medicine at Mount Sinai,Department of Psychiatry, Li Ka Shing Faculty of Medicine
[45] Icahn School of Medicine at Mount Sinai,State Key Laboratory for Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine
[46] Centre Hospitalier du Rouvray and INSERM U1079 Faculty of Medicine,Department of Computer Science
[47] University of California,Department of Psychiatry
[48] Schizophrenia Research Institute,Department of Child and Adolescent Psychiatry, Assistance Publique Hopitaux de Paris
[49] University of New South Wales,Department of Genetics
[50] University of Queensland,Department of Psychological Medicine
来源
Scientific Reports | / 8卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is −0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
引用
收藏
相关论文
共 50 条
  • [41] PRETERM BIRTH IS ASSOCIATED WITH INCREASED RISK OF MATERNAL AND NEONATAL INFECTION
    SEO, K
    MCGREGOR, JA
    FRENCH, JI
    OBSTETRICS AND GYNECOLOGY, 1992, 79 (01): : 75 - 80
  • [42] Higher parity and earlier age at first birth are associated with lower risk of death from colon cancer
    Kuo, Chao-Hung
    Kuo, Chien-Chun
    Wu, Hsiu-Yi
    Wu, Deng-Chyang
    Yang, Chun-Yuh
    CANCER SCIENCE, 2012, 103 (08): : 1553 - 1557
  • [43] Parity, age at first birth and the risk of carcinoma in situ of the breast
    Lambe, M
    Hsieh, CC
    Tsaih, SW
    Ekbom, A
    Trichopoulos, D
    Adami, HO
    INTERNATIONAL JOURNAL OF CANCER, 1998, 77 (03) : 330 - 332
  • [44] Age at first birth and melanoma risk: a meta-analysis
    Li, Zhengyong
    Gu, Mingjin
    Cen, Ying
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 7 (12): : 5201 - 5209
  • [45] Maternal age at first birth and boys' risk for conduct disorder
    Wakschlag, LS
    Gordon, RA
    Lahey, BB
    Loeber, R
    Green, SM
    Leventhal, BL
    JOURNAL OF RESEARCH ON ADOLESCENCE, 2000, 10 (04) : 417 - 441
  • [46] Is prior pregnancy loss associated with an increased risk for birth defects?
    Kucik, J.
    Alverson, C. J.
    Correa, A.
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 167 (11) : S22 - S22
  • [47] INCREASED MITOCHONDRIA CONTENT AND EPIGENETIC AGE ACCELERATION ARE INDEPENDENTLY ASSOCIATED WITH SCHIZOPHRENIA
    Ori, Anil
    Loohuis, Loes Olde
    Wu, Timothy
    Kahn, Rene S.
    Horvath, Steve
    Ophoff, Roel
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2017, 27 : S329 - S330
  • [48] Schizophrenia associated with increased risk of colon cancer but reduced risk of respiratory cancer
    Guo, Jeff J.
    EVIDENCE-BASED MENTAL HEALTH, 2008, 11 (03) : 93 - 93
  • [49] Early age at onset of schizophrenia and increased familial risk: Specificity of association
    Husted, J
    Greenwood, C
    Bassett, AS
    SCHIZOPHRENIA RESEARCH, 2001, 49 (1-2) : 33 - 34
  • [50] Predictors of young maternal age at first birth among women of reproductive age in Nigeria
    Bolarinwa, Obasanjo Afolabi
    Ahinkorah, Bright Opoku
    Seidu, Abdul-Aziz
    Mohammed, Aliu
    Effiong, Fortune Benjamin
    Hagan Jr, John Elvis
    Makinde, Olusesan Ayodeji
    PLOS ONE, 2023, 18 (01):