BRCA1-positive breast cancers in young women from Poland

被引：0

作者：

J. Lubiński

B. Górski

T. Huzarski

T. Byrski

J. Gronwald

P. Serrano-Fernández

W. Domagała

M. Chosia

M. Uciński

E. Grzybowska

D. Lange

B. Mąka

A. Mackiewicz

A. Karczewska

J. Bręborowicz

K. Lamperska

M. Stawicka

S. Gozdecka-Grodecka

M. Bębenek

D. Sorokin

A. Wojnar

O. Haus

J. Sir

T. Mierzwa

S. Niepsuj

K. Gugała

S. Góźdź

J. Sygut

B. Kozak-Klonowska

B. Musiatowicz

M. Posmyk

R. Kordek

M. Morawiec

O. Zambrano

B. Waśko

L. Fudali

J. Skręt

D. Surdyka

K. Urbański

J. Mituś

J. Ryś

M. Szwiec

A. Rozmiarek

I. Dziuba

P. Wandzel

R. Wiśniowski

C. Szczylik

A. Kozak

W. Kozłowski

S.A. Narod

机构：

[1] International Hereditary Cancer Center,Department of Genetics and Pathology

[2] Pomeranian Medical University,Department of Pathology

[3] Pomeranian Medical University,Department of Tumor Biology, Centre of Oncology

[4] Regional Oncology Hospital,Department of Clinical Genetics

[5] Maria Sklodowska-Curie Memorial Institute,Department of Chemotheraphy

[6] Poznań Medical University,Department of Gynecology

[7] Prophylactic and Epidemiology Center,Centre for Research in Women’s Health

[8] Regional Oncology Center,Department of Genetics and Pathology

[9] Regional Oncology Center,undefined

[10] Collegium Medicum,undefined

[11] Nicolaus Copernicus University,undefined

[12] Regional Oncology Hospital,undefined

[13] Regional Oncology Hospital,undefined

[14] Regional Oncology Center,undefined

[15] Regional Oncology Center,undefined

[16] Medical University,undefined

[17] Regional Hospital,undefined

[18] Medical Academy,undefined

[19] Regional Oncology Center,undefined

[20] Regional Oncology Center,undefined

[21] Regional Oncology Hospital,undefined

[22] Regional Hospital,undefined

[23] Regional Oncology Hospital,undefined

[24] Military Hospital,undefined

[25] University of Toronto,undefined

[26] International Hereditary Cancer Center,undefined

[27] Pomeranian Medical University,undefined

来源：

Breast Cancer Research and Treatment | 2006年 / 99卷

关键词：

BRCA1; genetics; hereditary breast cancer; pathology;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.

引用

页码：71 / 76

页数：5

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