No association between atopic asthma and a coding variant of FcεR1β in a Japanese population

被引：0
|
作者：
Mika Ishizawa
Masanao Shibasaki
Yukako Yokouchi
Emiko Noguchi
T. Arinami
Kimiko Yamakawa-Kobayashi
Akira Matsui
Hideo Hamaguchi
机构：
[1] Department of Medical Genetics,
[2] Institute of Basic Medical Sciences,undefined
[3] University of Tsukuba,undefined
[4] Tsukuba,undefined
[5] Ibaraki 305-8575,undefined
[6] Japan Tel. +81-298-53-3352; Fax +81-298-53-3177 e-mail: tarinami@md.tsukuba.ac.jp,undefined
[7] Department of Pediatrics,undefined
[8] Institute of Clinical Medicine,undefined
[9] University of Tsukuba,undefined
[10] Tsukuba,undefined
[11] Japan,undefined
来源：
Journal of Human Genetics | 1999年 / 44卷
关键词：
Key words Atopic asthma; IgE receptor; Polymorphism; Association; Transmission disequilibrium test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Susceptibility to atopic diseases is known to involve genetic factors. The Gly237 allele of a polymor-phism (Glu237Gly) of the FcεR1β gene is reportedly associated with atopic asthma in Japanese. To confirm this association, we conducted transmission disequilibrium tests in 76 families identified through atopic asthmatics. A case-control study was also carried out in atopic asth-matic subjects and non-atopic controls. The Gly237 allele was not preferentially transmitted to atopic asthma-affected offspring. Neither the Gly237 allele nor the Gly237/Gly237 + Glu237/Gly237 genotypes were significantly more prevalent in the atopic asthmatics than in the controls. This study failed to confirm a substantial role of the Gly237Glu polymorphism of the FcεR1β gene in the genetic predisposition for atopic asthma in this Japanese population.
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页码：308 / 311
页数：3
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