Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8

被引：0

作者：

Seung Beom Hong

Byeong-Won Kim

Kyung-Eun Lee

Se Woong Kim

Hyesung Jeon

Joon Kim

Hyun Kyu Song

机构：

[1] School of Life Sciences and Biotechnology,

[2] Korea University,undefined

[3] Biomedical Research Center,undefined

[4] Korea Institute of Science and Technology,undefined

来源：

Nature Structural & Molecular Biology | 2011年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The mechanism by which the noncanonical E1-like enzyme Atg7 activates ubiquitin-like Atg8 to trigger autophagy has not been well understood. The crystal structures of the N-terminal domain of Atg7 alone and C-terminal domain of Atg7 in complex with Atg8 show that this probably proceeds without the need for dramatic conformational rearrangements by Atg7, distinct from other E1 enzymes.

引用

页码：1323 / 1330

页数：7

共 50 条

[41] Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1
Singh, Rajesh K.
Kazansky, Yaniv
Wathieu, Donald
Fushman, David
ANALYTICAL CHEMISTRY, 2017, 89 (15) : 7852 - 7860
[42] E1 TRANSITIONS FROM OCTUPOLE VIBRATION STATES
COTTLE, PD
PHYSICAL REVIEW C, 1993, 47 (04): : 1529 - 1533
[43] On the nature of the Mn-related states in the band structure of (Ga,Mn)As alloys via probing the E1 and E1 + Δ1 optical transitions
Gluba, L.
Yastrubchak, O.
Sek, G.
Rudno-Rudzinski, W.
Sadowski, J.
Kulik, M.
Rzodkiewicz, W.
Rawski, M.
Andrearczyk, T.
Misiewicz, J.
Wosinski, T.
Zuk, J.
APPLIED PHYSICS LETTERS, 2014, 105 (03)
[44] GIANT E1 RESONANCES IN BE-8 FROM REACTION LI-7(P,GAMMA) BE-8
FISHER, GA
PAUL, P
RIESS, F
HANNA, SS
PHYSICAL REVIEW C, 1976, 14 (01): : 28 - 36
[45] The origin of the two isoforms of ubiquitin-activating enzyme (E1)
Shang, F
Deng, G
Wu, CN
Gong, X
Nowell, TR
Smith, D
Laursen, RA
Taylor, A
FASEB JOURNAL, 2000, 14 (08): : A1528 - A1528
[46] Production of Acidothermus cellulolyticus endoglucanase (E1) enzyme in transgenic rice
Oraby, Hesham
Ahmad, Rashid
Ransom, Callista
Sticklen, Mariam
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2005, 41 : 44A - 44A
[47] The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity
Chang, Tsui-Ling
Huang, Yi-Han
Ou, Yi-Dan
JOURNAL OF FUNCTIONAL FOODS, 2014, 7 : 462 - 470
[48] The development of a highly specific, sensitive enzyme immunoassay for prostaglandin E1
Linsky, R
Buckwalter, J
Schmidt, N
Scheuer, B
Hart, R
RECENT ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH, 1997, 433 : 423 - 426
[49] Molecular cloning of ubiquitin-activating enzyme (E1) from Xenopus laevis
Miya, F
Tokumoto, M
Nagahama, Y
Okida, N
Ishikawa, K
Tokumoto, T
DNA SEQUENCE, 2000, 11 (3-4): : 349 - 352
[50] High-level expression and purification of recombinant E1 enzyme
Beaudenon, S
Huibregtse, JM
UBIQUITIN AND PROTEIN DEGRADATION, PART A, 2005, 398 : 3 - 8

← 1 2 3 4 5 →