Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

被引：0
|
作者：
Yue-qin Wang
Ai-jun Shen
Jing-ya Sun
Xin Wang
Hong-chun Liu
Min-min Zhang
Dan-qi Chen
Bing Xiong
Jing-kang Shen
Mei-yu Geng
Min Zheng
Jian Ding
机构：
[1] China Pharmaceutical University,Department of New Drug Screening Center
[2] Division of Anti-tumor Pharmacology,Department of Thoracic Surgery
[3] Synthetic Organic and Medicinal Chemistry Laboratory,undefined
[4] State Key Laboratory of Drug Research,undefined
[5] Shanghai Institute of Materia Medica,undefined
[6] Chinese Academy of Sciences,undefined
[7] Shanghai Tongren Hospital,undefined
[8] Shanghai Jiao Tong University School of Medicine,undefined
来源：
Acta Pharmacologica Sinica | 2016年 / 37卷
关键词：
non-small cell lung cancer; gefitinib resistance; Hsp90;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1587 / 1596
页数：9
相关论文
共 50 条
  • [21] The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer
    Smith, Donald L.
    Acquaviva, Jaime
    Sequeira, Manuel
    Jimenez, John-Paul
    Zhang, Chaohua
    Sang, Jim
    Bates, Richard C.
    Proia, David A.
    TARGETED ONCOLOGY, 2015, 10 (02) : 235 - 245
  • [22] Sequence Dependent Radiosensitization of EGFR Mutant Non-small Cell Lung Cancer by Gefitinib Is Mediated by Senescence
    Huber, K. E.
    Iyer, V.
    Huber, W. E.
    Wazer, D. E.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (03): : S165 - S165
  • [23] PHASE II ACTIVITY OF THE HSP90 INHIBITOR AUY922 IN PATIENTS WITH EGFR-MUTANT ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC
    Barlesi, Fabrice
    Besse, Benjamin
    Chu, Quincy
    Gandhi, Leena
    Griesinger, Frank
    Felip, Enriqueta
    Kang, Jin Hyoung
    Kim, Sang-We
    Rosell, Rafael
    Sequist, Lecia V.
    Soo, Ross
    Wallmark, John
    Avsar, Emin
    Ofosu-Appiah, William
    Pain, Scott
    Akimov, Mikhail
    Garon, Edward B.
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S611 - S612
  • [24] The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer
    Donald L. Smith
    Jaime Acquaviva
    Manuel Sequeira
    John-Paul Jimenez
    Chaohua Zhang
    Jim Sang
    Richard C. Bates
    David A. Proia
    Targeted Oncology, 2015, 10 : 235 - 245
  • [25] Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non-Small Cell Lung Cancer
    Sang, Jim
    Acquaviva, Jaime
    Friedland, Julie C.
    Smith, Donald L.
    Sequeira, Manuel
    Zhang, Chaohua
    Jiang, Qin
    Xue, Liquan
    Lovly, Christine M.
    Jimenez, John-Paul
    Shaw, Alice T.
    Doebele, Robert C.
    He, Suqin
    Bates, Richard C.
    Camidge, D. Ross
    Morris, Stephan W.
    El-Hariry, Iman
    Proia, David A.
    CANCER DISCOVERY, 2013, 3 (04) : 430 - 443
  • [26] Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
    Yoon, Shinkyo
    Yang, Hannah
    Ryu, Hyun-Min
    Lee, Eunjin
    Jo, Yujin
    Seo, Seyoung
    Kim, Deokhoon
    Lee, Chang Hoon
    Kim, Wanlim
    Jung, Kyung Hae
    Park, Sook Ryun
    Choi, Eun Kyung
    Kim, Sang-We
    Park, Kang-Seo
    Lee, Dae Ho
    CANCER RESEARCH AND TREATMENT, 2022, 54 (03): : 767 - 781
  • [27] Efficacy of gefitinib at reduced dose in EGFR mutant non-small cell lung carcinoma
    Kwok, Wang Chun
    Ho, James Chung Man
    Tam, Terence Chi Chun
    Lui, Macy Mei Sze
    Ip, Mary Sau Man
    Lam, David Chi Leung
    ANTI-CANCER DRUGS, 2019, 30 (10) : 1048 - 1051
  • [28] Tackling Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer
    Blaquier, Juan Bautista
    Ortiz-Cuaran, Sandra
    Ricciuti, Biagio
    Mezquita, Laura
    Cardona, Andres Felipe
    Recondo, Gonzalo
    CLINICAL CANCER RESEARCH, 2023, 29 (18) : 3579 - 3591
  • [29] Gefitinib Plus Bevacizumab vs. Gefitinib Alone for EGFR Mutant Non-squamous Non-small Cell Lung Cancer
    Kitagawa, Chiyoe
    Mori, Masahide
    Ichiki, Masao
    Sukoh, Noriaki
    Kada, Akiko
    Saito, Akiko M.
    Ichinose, Yukito
    IN VIVO, 2019, 33 (02): : 477 - 482
  • [30] ROLE OF QUIESCENCE CANCER STEM CELLS IN THE GEFITINIB RESISTANCE IN EGFR MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER
    Hidayat, Moulid
    Takahashi, Fumiyuki
    Tajima, Ken
    Nurwidya, Fariz
    Wirawan, Aditya
    Kanemaru, Ryota
    Koinuma, Yoshika
    Hayakawa, Daisuke
    Tajima, Manabu
    Matsumoto, Naohisa
    Kanamori, Koichiro
    Takeda, Ikuko
    Kato, Motoyasu
    Kobayashi, Isao
    Shimada, Naoko
    Takahashi, Kazuhisa
    RESPIROLOGY, 2017, 22 : 18 - 19
12345