Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine

被引：0
|
作者：
Makoto Isono
Michèle J. Hoffmann
Maria Pinkerneil
Akinori Sato
Martin Michaelis
Jindrich Cinatl
Günter Niegisch
Wolfgang A. Schulz
机构：
[1] Heinrich-Heine-University Düsseldorf,Department of Urology, Medical Faculty
[2] National Defense Medical College,Department of Urology
[3] University of Kent,Centre for Molecular Processing and School of Biosciences
[4] Klinikum der Goethe-Universität,Institut für Medizinische Virologie
来源：
Journal of Experimental & Clinical Cancer Research | / 36卷
关键词：
Gemcitabine; AZD7762; Checkpoint kinase; Urothelial carcinoma; Bladder cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
    Isono, Makoto
    Hoffmann, Michele J.
    Pinkerneil, Maria
    Sato, Akinori
    Michaelis, Martin
    Cinatl, Jindrich, Jr.
    Niegisch, Guenter
    Schulz, Wolfgang A.
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017, 36 : 1 - 12
  • [2] Checkpoint Kinase Inhibitor AZD7762 Overcomes Cisplatin Resistance in Clear Cell Carcinoma of the Ovary
    Itamochi, Hiroaki
    Nishimura, Mayumi
    Oumi, Nao
    Kato, Misaki
    Oishi, Tetsuro
    Shimada, Muneaki
    Sato, Shinya
    Naniwa, Jun
    Sato, Seiya
    Kudoh, Akiko
    Kigawa, Junzo
    Harada, Tasuku
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014, 24 (01) : 61 - 69
  • [3] Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling
    Wang, Luqi
    Wang, Yue
    Chen, Andy
    Jalali, Aydin
    Liu, Shengzhi
    Guo, Yunxia
    Na, Sungsoo
    Nakshatri, Harikrishna
    Li, Bai-Yan
    Yokota, Hiroki
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 53 (03) : 1001 - 1012
  • [4] Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
    Zhu, Jian
    Zou, Hanhui
    Yu, Wei
    Huang, Yuluan
    Liu, Bing
    Li, Tao
    Liang, Chengzhen
    Tao, Huimin
    CANCER CELL INTERNATIONAL, 2019, 19 (1)
  • [5] Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
    Jian Zhu
    Hanhui Zou
    Wei Yu
    Yuluan Huang
    Bing Liu
    Tao Li
    Chengzhen Liang
    Huimin Tao
    Cancer Cell International, 19
  • [6] In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762
    Mitchell, James B.
    Choudhuri, Rajani
    Fabre, Kristin
    Sowers, Anastasia L.
    Citrin, Deborah
    Zabludoff, Sonya D.
    Cook, John A.
    CLINICAL CANCER RESEARCH, 2010, 16 (07) : 2076 - 2084
  • [7] AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
    Zabludoff, Sonya D.
    Deng, Chun
    Grondine, Michael R.
    Sheehy, Adam M.
    Ashwell, Susan
    Caleb, Benjamin L.
    Green, Stephen
    Haye, Heather R.
    Horn, Candice L.
    Janetka, James W.
    Liu, Dongfang
    Mouchet, Elizabeth
    Ready, Shannon
    Rosenthal, Judith L.
    Queva, Christophe
    Schwartz, Gary K.
    Taylor, Karen J.
    Tse, Archie N.
    Walker, Graeme E.
    White, Anne M.
    MOLECULAR CANCER THERAPEUTICS, 2008, 7 (09) : 2955 - 2966
  • [8] Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
    Edward Sausville
    Patricia LoRusso
    Michael Carducci
    Judith Carter
    Mary F. Quinn
    Lisa Malburg
    Nilofer Azad
    David Cosgrove
    Richard Knight
    Peter Barker
    Sonya Zabludoff
    Felix Agbo
    Patricia Oakes
    Adrian Senderowicz
    Cancer Chemotherapy and Pharmacology, 2014, 73 : 539 - 549
  • [9] Preclinical identification of AZD7762, a novel, potent and selective inhibitor of Checkpoint kinases
    Ashwell, Susan
    Caleb, Benjamin L.
    Deng, Chun
    Green, Stephen
    Grondine, Michael R.
    Haye, Heather R.
    Horn, Candice L.
    Janetka, James W.
    Liu, Dongfang
    Mouchet, Elizabeth
    Ready, Shannon
    Rosenthal, Judith L.
    Queva, Christophe
    Taylor, Karen J.
    Sheehy, Adam M.
    Walker, Graeme E.
    White, Anne M.
    Zabludoff, Sonya D.
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3411S - 3411S
  • [10] Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
    Sausville, Edward
    LoRusso, Patricia
    Carducci, Michael
    Carter, Judith
    Quinn, Mary F.
    Malburg, Lisa
    Azad, Nilofer
    Cosgrove, David
    Knight, Richard
    Barker, Peter
    Zabludoff, Sonya
    Agbo, Felix
    Oakes, Patricia
    Senderowicz, Adrian
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 73 (03) : 539 - 549
12345