Suppression of CD8+ T cells by the metabolite itaconate

被引：0
|
作者：
机构：
来源：
Nature Metabolism | 2022年 / 4卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The immune-modulatory metabolite itaconate is secreted by myeloid-derived suppressor cells and taken up by CD8+ T cells to suppress their proliferation and function. In mice, blocking itaconate production enhances the efficacy of immune checkpoint blockade.
引用
收藏
页码：1626 / 1627
页数：1
相关论文
共 50 条
  • [41] In vitro and In vivo CD8+ T Cell Suppression Assays
    Xie, Lu
    Liu, Guihuan
    Liu, Yanjun
    Yu, Yuming
    BIO-PROTOCOL, 2021, 11 (10):
  • [42] CONTRA - CD8+ T-CELL-MEDIATED SUPPRESSION WITHOUT SUPPRESSOR T-CELLS
    ZINKERNAGEL, RM
    HENGARTNER, H
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1993, 100 (01) : 8 - 11
  • [43] CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells
    Robertson, Shelly J.
    Messer, Ronald J.
    Carmody, Aaron B.
    Mittler, Robert S.
    Burlak, Christopher
    Hasenkrug, Kim J.
    JOURNAL OF IMMUNOLOGY, 2008, 180 (08): : 5267 - 5274
  • [44] Regulatory T cells suppression of antigen-specific CD8+ T cells in vivo is contact-dependent
    Mansoori, Mohammad Nizam
    Shevach, Ethan Menahem
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [45] Heterogeneity of CD4+ and CD8+ T cells
    Woodland, DL
    Dutton, RW
    CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (03) : 336 - 342
  • [46] Suppression of Primary Allogenic Response by CD8+ Memory Cells
    T. S. Grinenko
    E. L. Pobezinskaya
    L. A. Pobezinskii
    I. A. Baturina
    E. S. Zvezdova
    D. B. Kazanskii
    Bulletin of Experimental Biology and Medicine, 2005, 140 : 545 - 549
  • [47] Suppression of primary allogenic response by CD8+ memory cells
    Grinenko, TS
    Pobezinskaya, EL
    Pobezinskii, LA
    Baturina, IA
    Zvezdova, ES
    Kazanskii, DB
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 140 (05) : 545 - 549
  • [48] CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease
    Strioga, Marius
    Pasukoniene, Vita
    Characiejus, Dainius
    IMMUNOLOGY, 2011, 134 (01) : 17 - 32
  • [49] CD8+ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System
    Marcondes, Maria Cecilia G.
    Morsey, Brenda
    Emanuel, Katy
    Lamberty, Benjamin G.
    Flynn, Claudia T.
    Fox, Howard S.
    JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (01): : 40 - 44
  • [50] Protective HIV-specific CD8+ T cells evade Treg cell suppression
    Elahi, Shokrollah
    Dinges, Warren L.
    Lejarcegui, Nicholas
    Laing, Kerry J.
    Collier, Ann C.
    Koelle, David M.
    McElrath, M. Juliana
    Horton, Helen
    NATURE MEDICINE, 2011, 17 (08) : 989 - U110
12345