Suppression of CD8+ T cells by the metabolite itaconate

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Nature Metabolism | 2022年 / 4卷
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The immune-modulatory metabolite itaconate is secreted by myeloid-derived suppressor cells and taken up by CD8+ T cells to suppress their proliferation and function. In mice, blocking itaconate production enhances the efficacy of immune checkpoint blockade.
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页码：1626 / 1627
页数：1
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