Genetically encoded intracellular sensors based on fluorescent proteins

被引：0
|
作者：
E. A. Souslova
D. M. Chudakov
机构：
[1] Russian Academy of Sciences,Shemyakin
来源：
Biochemistry (Moscow) | 2007年 / 72卷
关键词：
genetically encoded sensors; fluorescent proteins; mutant GFP variants; FRET;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Green fluorescent protein from Aequorea victoria and its many homologs are now widely used in basic and applied research. These genetically encoded fluorescent markers can detect localization of cell proteins and organelles in living cells and also cells and tissues in living organisms. Unique instruments and methods for studies of molecular biology of a cell and high throughput drug screenings are based on fluorescent proteins. This review deals with the most intensively evolving directions in this field, the development of genetically encoded sensors. Changes in their spectral properties are used for monitoring of cell enzyme activities or changes in concentrations of particular molecules.
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页码：683 / 697
页数：14
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