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Partial genomic survival of cave bears in living brown bears
被引:0
|作者:
Axel Barlow
James A. Cahill
Stefanie Hartmann
Christoph Theunert
Georgios Xenikoudakis
Gloria G. Fortes
Johanna L. A. Paijmans
Gernot Rabeder
Christine Frischauf
Aurora Grandal-d’Anglade
Ana García-Vázquez
Marine Murtskhvaladze
Urmas Saarma
Peeter Anijalg
Tomaž Skrbinšek
Giorgio Bertorelle
Boris Gasparian
Guy Bar-Oz
Ron Pinhasi
Montgomery Slatkin
Love Dalén
Beth Shapiro
Michael Hofreiter
机构:
[1] University of Potsdam,Institute for Biochemistry and Biology
[2] University of California,Department of Ecology and Evolutionary Biology
[3] Santa Cruz,Department of Integrative Biology
[4] University of California,Department of Evolutionary Genetics
[5] Berkeley,Department of Life Sciences and Biotechnology
[6] Max Planck Institute for Evolutionary Anthropology,Institute of Palaeontology
[7] University of Ferrara,Department of Zoology, Institute of Ecology and Earth Sciences
[8] University of Vienna,Department of Biology, Biotechnical Faculty
[9] Instituto Universitario de Xeoloxía,Institute of Archaeology and Ethnography
[10] Universidade da Coruña,Zinman Institute of Archaeology
[11] Ilia State University,Earth Institute
[12] Institute of Ecology,Department of Evolutionary Anthropology
[13] University of Tartu,Department of Bioinformatics and Genetics
[14] University of Ljubljana,undefined
[15] National Academy of Sciences of the Republic of Armenia,undefined
[16] University of Haifa,undefined
[17] University College Dublin,undefined
[18] University of Vienna,undefined
[19] Swedish Museum of Natural History,undefined
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摘要:
Although many large mammal species went extinct at the end of the Pleistocene epoch, their DNA may persist due to past episodes of interspecies admixture. However, direct empirical evidence of the persistence of ancient alleles remains scarce. Here, we present multifold coverage genomic data from four Late Pleistocene cave bears (Ursus spelaeus complex) and show that cave bears hybridized with brown bears (Ursus arctos) during the Pleistocene. We develop an approach to assess both the directionality and relative timing of gene flow. We find that segments of cave bear DNA still persist in the genomes of living brown bears, with cave bears contributing 0.9 to 2.4% of the genomes of all brown bears investigated. Our results show that even though extinction is typically considered as absolute, following admixture, fragments of the gene pool of extinct species can survive for tens of thousands of years in the genomes of extant recipient species.
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页码:1563 / 1570
页数:7
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