Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation

被引：0
|
作者：
Kuroiwa, Kai [1 ]
Sato, Misuzu [2 ]
Narita, Hinako [1 ]
Okamura, Reiko [1 ]
Uesugi, Yuka [1 ]
Sasaki, Yohei [1 ]
Shimada, Shotaro [1 ]
Watanuki, Megumi [1 ]
Fujiwara, Shun [1 ]
Kawaguchi, Yukiko [1 ]
Arai, Nana [1 ]
Yanagisawa, Kouji [1 ]
Iezumi, Keiichi [2 ]
Hattori, Norimichi [1 ]
机构：
[1] Showa Univ, Sch Med, Dept Med, Div Hematol,Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428666, Japan
[2] Showa Univ, Sch Med, Dept Pathol & Lab Med, Tokyo, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024年 / 119卷 / 05期
关键词：
Allogeneic hematopoietic stem cell transplantation; FOXP3; Polymorphism; Graft-versus-host disease; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; ASSOCIATION; IMBALANCE; INDEX;
D O I：
10.1007/s12185-024-03726-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3-3279C/A or FOXP3-3279A/A genotype than those with the FOXP3-3279C/C genotype [hazard ratio (HR), 2.69; 95% confidence interval (CI) 1.14-6.31; p = 0.023]. Therefore, FOXP3 at SNP rs3761548 can be a useful marker for predicting the occurrence of severe cGVHD.
引用
收藏
页码：583 / 591
页数：9
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