Antioxidants and CVD in diabetes: Where do we stand now?

被引：27
|
作者：
Yim S. [1 ]
Malhotra A. [1 ]
Veves A. [1 ]
机构：
[1] Microcirculation Laboratory, Palmer 321A, Beth Israel Deaconess Medical Center, Boston, MA 02215, One Deaconess Road
来源：
Current Diabetes Reports | 2007年 / 7卷 / 1期
基金：
美国国家卫生研究院;
关键词：
Endothelial Dysfunction; Physiol Heart Circ; Polyol Pathway; Benfotiamine; Smooth Muscle Cell Growth;
D O I：
10.1007/s11892-007-0003-9
中图分类号：
学科分类号：
摘要：
Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option. Copyright © 2007 by Current Medicine Group LLC.
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页码：8 / 13
页数：5
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