LEF1 turns over a new leaf

被引：0
|
作者：
Wim de Lau
Hans Clevers
机构：
[1] University Medical Center,Department of Immunology and Center for Biomedical Genetics
来源：
Nature Genetics | 2001年 / 28卷 / 1期
关键词：
D O I：
10.1038/ng0501-3
中图分类号：
学科分类号：
摘要：
LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.
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页码：3 / 4
页数：1
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