LEF1 turns over a new leaf

被引：0

作者：

Wim de Lau

Hans Clevers

机构：

[1] University Medical Center,Department of Immunology and Center for Biomedical Genetics

来源：

Nature Genetics | 2001年 / 28卷 / 1期

关键词：

D O I：

10.1038/ng0501-3

中图分类号：

学科分类号：

摘要：

LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.

引用

页码：3 / 4

页数：1

共 50 条

[1] LEF1 turns over a new leaf
de Lau, W
Clevers, H
NATURE GENETICS, 2001, 28 (01) : 3 - 4
[2] PALEOBOTANY TURNS OVER A NEW LEAF
KNOLL, AH
PALEOBIOLOGY, 1980, 6 (01) : 1 - 2
[3] Electronics turns over a new leaf
Berggren, M
Kugler, T
PHYSICS WORLD, 2001, 14 (07) : 21 - 22
[4] Tobacco turns over a new leaf
Hoyle, B
ASM NEWS, 2001, 67 (12): : 603 - 604
[5] Climate science turns over a new leaf
Calder, N
CHEMISTRY & INDUSTRY, 2000, (02) : 53 - 54
[6] Phylogenetic systematics turns over a new leaf
Lewis, PO
TRENDS IN ECOLOGY & EVOLUTION, 2001, 16 (01) : 30 - 37
[7] Maple V turns over a new leaf
Shirer, DL
COMPUTERS IN PHYSICS, 1998, 12 (03): : 267 - 268
[8] Skin care turns over a new leaf
Place, J
SOAP COSMETICS CHEMICAL SPECIALTIES, 1998, 74 (02): : 26 - +
[9] Maternal and embryonic expression of zebrafish lef1
Dorsky, RI
Snyder, A
Cretekos, CJ
Grunwald, DJ
Geisler, R
Haffter, P
Moon, RT
Raible, DW
MECHANISMS OF DEVELOPMENT, 1999, 86 (1-2) : 147 - 150
[10] LEF1 Immunohistochemistry in the Evaluation of Medulloblastoma Subgroups
Thomas, Diana
Murdoch, Geoffrey
Hamilton, Ronald
Orr, Brent
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2018, 77 (06): : 514 - 515

← 1 2 3 4 5 →