ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

被引：0

作者：

Jochen C Hartner

Carl R Walkley

Jun Lu

Stuart H Orkin

机构：

[1] Dana-Farber Cancer Institute; Harvard Medical School,Department of Pediatric Oncology

[2] Harvard Medical School,Division of Hematology

[3] Children's Hospital Boston,Oncology

[4] Broad Institute of MIT and Harvard,undefined

[5] Howard Hughes Medical Institute,undefined

[6] Harvard Stem Cell Institute,undefined

[7] Present address: St. Vincent's Institute of Medical Research,undefined

[8] Princes Street,undefined

[9] Fitzroy,undefined

[10] Victoria 3065,undefined

[11] Australia.,undefined

来源：

Nature Immunology | 2009年 / 10卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

ADAR1 is an adenosine deaminase that acts on double-stranded RNA. Orkin and colleagues show that ADAR1 protects hematopoietic stem cells from interferon-induced insult and is needed to maintain long-term hematopoiesis.

引用

页码：109 / 115

页数：6

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