ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

被引：0
|
作者：
Jochen C Hartner
Carl R Walkley
Jun Lu
Stuart H Orkin
机构：
[1] Dana-Farber Cancer Institute; Harvard Medical School,Department of Pediatric Oncology
[2] Harvard Medical School,Division of Hematology
[3] Children's Hospital Boston,Oncology
[4] Broad Institute of MIT and Harvard,undefined
[5] Howard Hughes Medical Institute,undefined
[6] Harvard Stem Cell Institute,undefined
[7] Present address: St. Vincent's Institute of Medical Research,undefined
[8] Princes Street,undefined
[9] Fitzroy,undefined
[10] Victoria 3065,undefined
[11] Australia.,undefined
来源：
Nature Immunology | 2009年 / 10卷
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学科分类号：
摘要：
ADAR1 is an adenosine deaminase that acts on double-stranded RNA. Orkin and colleagues show that ADAR1 protects hematopoietic stem cells from interferon-induced insult and is needed to maintain long-term hematopoiesis.
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页码：109 / 115
页数：6
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