Cdc14 phosphatase resolves the rDNA segregation delay

被引：0
|
作者：
Gislene Pereira
Elmar Schiebel
机构：
[1] the School of Biological Sciences,
[2] University of Manchester,undefined
[3] the Paterson Institute for Cancer Research,undefined
来源：
Nature Cell Biology | 2004年 / 6卷
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摘要：
Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.
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页码：473 / 475
页数：2
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