Role of Serological Tests in the Diagnosis of Mold Infections

被引：54

作者：

Richardson M. ^{[1
,2
]}

Page I. ^{[2
,3
]}

机构：

[1] Mycology Reference Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester

[2] Division of Infection, Inflammation and Respiratory Medicine, Faculty of Biology, Medcine and Health, The University of Manchester, Manchester

[3] National Aspergillus Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester

来源：

Current Fungal Infection Reports | 2018年 / 12卷 / 3期

关键词：

Allergic bronchopulmonary aspergillosis; Allergic bronchopulmonary mycoses; Antibody assays; Aspergillus; Chronic pulmonary aspergillosis; Filamentous fungi; Molds; Mucormycosis; Pythiosis; Serology; Talaromyces;

D O I：

10.1007/s12281-018-0321-1

中图分类号：

学科分类号：

摘要：

Purpose of Review: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades, antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. Recent Findings: This article reviews the current antibody detection systems (serological tests) for the diagnosis of mold infections associated with pulmonary disease and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation, and ELISA. Summary: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing. © 2018, The Author(s).

引用

页码：127 / 136

页数：9

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