Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

被引：0

作者：

Praveen Surendran

Fotios Drenos

Robin Young

Helen Warren

James P Cook

Alisa K Manning

Niels Grarup

Xueling Sim

Daniel R Barnes

Kate Witkowska

James R Staley

Vinicius Tragante

Taru Tukiainen

Hanieh Yaghootkar

Nicholas Masca

Daniel F Freitag

Teresa Ferreira

Olga Giannakopoulou

Andrew Tinker

Magdalena Harakalova

Evelin Mihailov

Chunyu Liu

Aldi T Kraja

Sune Fallgaard Nielsen

Asif Rasheed

Maria Samuel

Wei Zhao

Lori L Bonnycastle

Anne U Jackson

Narisu Narisu

Amy J Swift

Lorraine Southam

Jonathan Marten

Jeroen R Huyghe

Alena Stančáková

Cristiano Fava

Therese Ohlsson

Angela Matchan

Kathleen E Stirrups

Jette Bork-Jensen

Anette P Gjesing

Jukka Kontto

Markus Perola

Susan Shaw-Hawkins

Aki S Havulinna

He Zhang

Louise A Donnelly

Christopher J Groves

N William Rayner

Matt J Neville

机构：

[1] MRC/BHF Cardiovascular Epidemiology Unit,Department of Public Health and Primary Care

[2] University of Cambridge,Department of Health Sciences

[3] Medical Research Council Integrative Epidemiology Unit,Department of Biostatistics

[4] School of Social and Community Medicine,Department of Genetics

[5] University of Bristol,Department of Molecular Biology

[6] Oakfield House,Department of Biostatistics

[7] Oakfield Grove,Department of Cardiology

[8] Centre for Cardiovascular Genetics,Department of Medicine

[9] Institute of Cardiovascular Science,Department of Cardiovascular Sciences

[10] University College London,Nuffield Department of Medicine

[11] Clinical Pharmacology,Division of Statistical Genomics

[12] William Harvey Research Institute,Department of Genetics

[13] Queen Mary University of London,Department of Clinical Biochemistry Herlev Hospital

[14] National Institute for Health Research Barts Cardiovascular Biomedical Research Unit,Department of Biostatistics and Epidemiology

[15] Queen Mary University of London,Department of Medicine

[16] University of Leicester,Department of Clinical Sciences

[17] University of Liverpool,Department of Medicine

[18] Harvard Medical School,Department of Haematology

[19] Program in Medical and Population Genetics,Department of Health

[20] Broad Institute,Department of Internal Medicine, Division of Cardiovascular Medicine

[21] Massachusetts General Hospital,Radcliffe Department of Medicine

[22] Novo Nordisk Foundation Center for Basic Metabolic Research,Department of Life Sciences

[23] Faculty of Health and Medical Sciences,Department of Gastroenterology and Metabolism

[24] University of Copenhagen,Department of Obstetrics and Gynaecology

[25] Center for Statistical Genetics,Department of Epidemiology and Biostatistics

[26] University of Michigan,Department of Cardiology

[27] University of Michigan,Department of Public Health and Caring Sciences

[28] Saw Swee Hock School of Public Health,Department of Neurosciences

[29] National University of Singapore,Department of Cardiology

[30] National University Health System,Department of Hygiene and Epidemiology

[31] University Medical Center Utrecht,Department of Clinical Sciences

[32] Analytic and Translational Genetics Unit,Department of Genetics

[33] Massachusetts General Hospital,Department of Gerontology and Geriatrics

[34] Genetics of Complex Traits,Department of Cardiology

[35] Institute of Biomedical and Clinical Science,Department of Psychology

[36] University of Exeter Medical School,Department of Twin Research and Genetic Epidemiology

[37] University of Leicester,Department of Nutrition and Dietetics

[38] National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease,Department of Biobank Research

[39] Wellcome Trust Centre for Human Genetics,Department of Medicine

[40] University of Oxford,Department of Medicine

[41] Heart Centre,Department of Epidemiology

[42] William Harvey Research Institute,Department of Medicine

[43] Barts and The London School of Medicine and Dentistry,Department of Epidemiology

[44] Queen Mary University of London,Department of Public Health and Clinical Nutrition

[45] Estonian Genome Center,Department of Clinical Physiology and Nuclear Medicine

[46] University of Tartu,Department of Public Health and Clinical Medicine

[47] National Heart,Department of Nutrition

[48] Lung,Division of Endocrinology

[49] and Blood Institute's and Boston University's Framingham Heart Study,Department of Genetics

[50] Center for Genome Sciences and Systems Biology,Division of Nephrology, Department of Internal Medicine and Medical Specialties

来源：

Nature Genetics | 2016年 / 48卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their analyses provide insights into the pathophysiology of hypertension and highlight new potential targets for clinical intervention.

引用

页码：1151 / 1161

页数：10

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