Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

被引：0

作者：

Praveen Surendran

Fotios Drenos

Robin Young

Helen Warren

James P Cook

Alisa K Manning

Niels Grarup

Xueling Sim

Daniel R Barnes

Kate Witkowska

James R Staley

Vinicius Tragante

Taru Tukiainen

Hanieh Yaghootkar

Nicholas Masca

Daniel F Freitag

Teresa Ferreira

Olga Giannakopoulou

Andrew Tinker

Magdalena Harakalova

Evelin Mihailov

Chunyu Liu

Aldi T Kraja

Sune Fallgaard Nielsen

Asif Rasheed

Maria Samuel

Wei Zhao

Lori L Bonnycastle

Anne U Jackson

Narisu Narisu

Amy J Swift

Lorraine Southam

Jonathan Marten

Jeroen R Huyghe

Alena Stančáková

Cristiano Fava

Therese Ohlsson

Angela Matchan

Kathleen E Stirrups

Jette Bork-Jensen

Anette P Gjesing

Jukka Kontto

Markus Perola

Susan Shaw-Hawkins

Aki S Havulinna

He Zhang

Louise A Donnelly

Christopher J Groves

N William Rayner

Matt J Neville

机构：

[1] MRC/BHF Cardiovascular Epidemiology Unit,Department of Public Health and Primary Care

[2] University of Cambridge,Department of Health Sciences

[3] Medical Research Council Integrative Epidemiology Unit,Department of Biostatistics

[4] School of Social and Community Medicine,Department of Genetics

[5] University of Bristol,Department of Molecular Biology

[6] Oakfield House,Department of Biostatistics

[7] Oakfield Grove,Department of Cardiology

[8] Centre for Cardiovascular Genetics,Department of Medicine

[9] Institute of Cardiovascular Science,Department of Cardiovascular Sciences

[10] University College London,Nuffield Department of Medicine

[11] Clinical Pharmacology,Division of Statistical Genomics

[12] William Harvey Research Institute,Department of Genetics

[13] Queen Mary University of London,Department of Clinical Biochemistry Herlev Hospital

[14] National Institute for Health Research Barts Cardiovascular Biomedical Research Unit,Department of Biostatistics and Epidemiology

[15] Queen Mary University of London,Department of Medicine

[16] University of Leicester,Department of Clinical Sciences

[17] University of Liverpool,Department of Medicine

[18] Harvard Medical School,Department of Haematology

[19] Program in Medical and Population Genetics,Department of Health

[20] Broad Institute,Department of Internal Medicine, Division of Cardiovascular Medicine

[21] Massachusetts General Hospital,Radcliffe Department of Medicine

[22] Novo Nordisk Foundation Center for Basic Metabolic Research,Department of Life Sciences

[23] Faculty of Health and Medical Sciences,Department of Gastroenterology and Metabolism

[24] University of Copenhagen,Department of Obstetrics and Gynaecology

[25] Center for Statistical Genetics,Department of Epidemiology and Biostatistics

[26] University of Michigan,Department of Cardiology

[27] University of Michigan,Department of Public Health and Caring Sciences

[28] Saw Swee Hock School of Public Health,Department of Neurosciences

[29] National University of Singapore,Department of Cardiology

[30] National University Health System,Department of Hygiene and Epidemiology

[31] University Medical Center Utrecht,Department of Clinical Sciences

[32] Analytic and Translational Genetics Unit,Department of Genetics

[33] Massachusetts General Hospital,Department of Gerontology and Geriatrics

[34] Genetics of Complex Traits,Department of Cardiology

[35] Institute of Biomedical and Clinical Science,Department of Psychology

[36] University of Exeter Medical School,Department of Twin Research and Genetic Epidemiology

[37] University of Leicester,Department of Nutrition and Dietetics

[38] National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease,Department of Biobank Research

[39] Wellcome Trust Centre for Human Genetics,Department of Medicine

[40] University of Oxford,Department of Medicine

[41] Heart Centre,Department of Epidemiology

[42] William Harvey Research Institute,Department of Medicine

[43] Barts and The London School of Medicine and Dentistry,Department of Epidemiology

[44] Queen Mary University of London,Department of Public Health and Clinical Nutrition

[45] Estonian Genome Center,Department of Clinical Physiology and Nuclear Medicine

[46] University of Tartu,Department of Public Health and Clinical Medicine

[47] National Heart,Department of Nutrition

[48] Lung,Division of Endocrinology

[49] and Blood Institute's and Boston University's Framingham Heart Study,Department of Genetics

[50] Center for Genome Sciences and Systems Biology,Division of Nephrology, Department of Internal Medicine and Medical Specialties

来源：

Nature Genetics | 2016年 / 48卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their analyses provide insights into the pathophysiology of hypertension and highlight new potential targets for clinical intervention.

引用

页码：1151 / 1161

页数：10

共 50 条

[1] Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran, Praveen
Drenos, Fotios
Young, Robin
Warren, Helen
Cook, James P.
Manning, Alisa K.
Grarup, Niels
Sim, Xueling
Barnes, Daniel R.
Witkowska, Kate
Staley, James R.
Tragante, Vinicius
Tukiainen, Taru
Yaghootkar, Hanieh
Masca, Nicholas
Freitag, Daniel F.
Ferreira, Teresa
Giannakopoulou, Olga
Tinker, Andrew
Harakalova, Magdalena
Mihailov, Evelin
Liu, Chunyu
Kraja, Aldi T.
Nielsen, Sune Fallgaard
Rasheed, Asif
Samue, Maria
Zhao, Wei
Bonnycastle, Lori L.
Jackson, Anne U.
Narisu, Narisu
Swift, Amy J.
Southam, Lorraine
Marten, Jonathan
Huyghe, Jeroen R.
Stancakova, Alena
Fava, Cristiano
Ohlsson, Therese
Matchan, Angela
Stirrups, Kathleen E.
Bork-Jensen, Jette
Gjesing, Anette P.
Kontto, Jukka
Perola, Markus
Shaw-Hawkins, Susan
Havulinna, Aki S.
Zhang, He
Donnelly, Louise A.
Groves, Christopher J.
Rayner, N. William
Neville, Matt J.
[J]. NATURE GENETICS, 2016, 48 (10) : 1151 - 1161
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[J]. DIABETOLOGIA, 2016, 59 : S60 - S60
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[10] Response to Resistance Training, Blood Pressure, and Meta-Analyses
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