Fabrication of the Components for a Sustained-Release Injectable Dosage Form of Acetylsalicylic Acid Using Supercritical Carbon Dioxide

被引：0
|
作者：
E. N. Antonov
S. E. Bogorodskii
L. I. Krotova
V. K. Popov
V. Yu. Belov
S. V. Kursakov
V. I. Sevastyanov
机构：
[1] Russian Academy of Sciences,Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics
[2] Institute of Medical and Biological Research and Technologies,undefined
[3] Shumakov Federal Research Center of Transplantology and Artificial Organs,undefined
来源：
Russian Journal of Physical Chemistry B | 2017年 / 11卷
关键词：
sustained-release drug forms; polymeric microparticles; encapsulation of bioactive components; supercritical carbon dioxide; acetylsalicylic acid; release kinetics; HPLC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fabrication of fine-grained (10–100 μm) bioresorbable powders of aliphatic polyesters containing therapeutically significant (up to 10 wt %) concentrations of acetylsalicylic acid using supercritical CO2 is studied. The process for fabricating the components of sustained-release injectable dosage forms of acetylsalicylic acid is elaborated. The kinetics of release of acetylsalicylic acid from polylactide microparticles into the normal saline solution in vitro is studied by high-performance liquid chromatography.
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页码：1056 / 1060
页数：4
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