Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

被引：0

作者：

Dinesh Aggarwal

Andrew J. Page

Ulf Schaefer

George M. Savva

Richard Myers

Erik Volz

Nicholas Ellaby

Steven Platt

Natalie Groves

Eileen Gallagher

Niamh M. Tumelty

Thanh Le Viet

Gareth J. Hughes

Cong Chen

Charlie Turner

Sophie Logan

Abbie Harrison

Sharon J. Peacock

Meera Chand

Ewan M. Harrison

机构：

[1] University of Cambridge,Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases

[2] Department of Medicine,Clinical Microbiology Department

[3] Public Health England,Department of Infection Biology, Faculty of Infectious & Tropical Diseases

[4] Cambridge University Hospital NHS Foundation Trust,Department of Infectious Diseases

[5] Wellcome Sanger Institute,Department of Microbiology

[6] Hinxton,Department of Zoology

[7] Quadram Institute Bioscience,Departments of Infectious Diseases and Microbiology

[8] Norwich Research Park,Division of Virology, Department of Pathology

[9] Imperial College London,undefined

[10] Department of Infectious Disease Epidemiology,undefined

[11] University of Cambridge,undefined

[12] Cambridge University Libraries,undefined

[13] Public Health England National Infections Service,undefined

[14] Field Service,undefined

[15] Public Health England,undefined

[16] National Infections Service,undefined

[17] Field Service,undefined

[18] University of Cambridge,undefined

[19] Department of Public Health and Primary Care,undefined

[20] Barking,undefined

[21] Havering and Redbridge University Hospitals NHS Trust,undefined

[22] Basingstoke Hospital,undefined

[23] Belfast Health & Social Care Trust,undefined

[24] Betsi Cadwaladr University Health Board,undefined

[25] Big Data Institute,undefined

[26] Nuffield Department of Medicine,undefined

[27] University of Oxford,undefined

[28] Brighton and Sussex University Hospitals NHS Trust,undefined

[29] Cambridge Stem Cell Institute,undefined

[30] University of Cambridge,undefined

[31] Cardiff and Vale University Health Board,undefined

[32] Cardiff University,undefined

[33] Centre for Clinical Infection & Diagnostics Research,undefined

[34] St. Thomas’ Hospital and Kings College London,undefined

[35] Guy’s and St Thomas’ NHS Foundation Trust,undefined

[36] Centre for Enzyme Innovation,undefined

[37] University of Portsmouth (PORT),undefined

[38] Centre for Genomic Pathogen Surveillance,undefined

[39] University of Oxford,undefined

[40] Queens Medical Centre,undefined

[41] Clinical Microbiology,undefined

[42] University Hospitals of Leicester NHS Trust,undefined

[43] County Durham and Darlington NHS Foundation Trust,undefined

[44] Deep Seq,undefined

[45] School of Life Sciences,undefined

[46] Queens Medical Centre,undefined

[47] University of Nottingham,undefined

[48] London School of Hygiene & Tropical Medicine,undefined

[49] King’s College London,undefined

[50] Kettering General Hospital,undefined

来源：

Nature Communications | / 13卷

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摘要：

Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

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