Synthesis of perillyl-containing meroterpenoids and their supramolecular self-assembly with pillar[5]arene

被引：0
|
作者：
Akhmedov, A. A. [1 ,2 ]
Panina, Yu. V. [1 ]
Gamirov, R. R. [1 ]
Shurpik, D. N. [1 ]
Stoikov, I. I. [1 ,2 ]
机构：
[1] Kazan Volga Reg Fed Univ, AM Butlerov Chem Inst, 18 Ul Kremlevskaya, Kazan 420008, Russia
[2] Fed Ctr Toxicol Radiat & Biol Safety, Nauchnyi Gorodok 2, Kazan 420075, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2024年 / 73卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
terpenoids; meroterpenoids; perillyl alcohol; macrocyclic systems; pillar[5]-arene; associates; host-guest systems; inclusion complex; DRUG-DELIVERY; COMPLEXES; GUESTS;
D O I：
10.1007/s11172-024-4174-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The S-perillyl alcohol derivatives containing pyridinium and imidazolium fragments were synthesized. The 2: 1 host-guest complex with model pillar[5]arene characterized by logKass = 6.13 was synthesized from perillyl-bearing meroterpenoid. The composition and structure of the synthesized complex were confirmed by 1H and 2D 1H-1H NOESY NMR spectroscopy. The properties of associates formed by the meroterpenoid-pillar[5]-arene complexes were evaluated by dynamic light scattering, Doppler microelectrophoresis, and transmission electron microscopy. The studied systems are characterized by average hydrodynamic diameters of 191-345 nm and polydispersity indices of 0.18-0.32.
引用
收藏
页码：644 / 652
页数：9
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