Synthesis of New 7-bromo-5-(2’-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine Derivatives and Their Influence on Appetite in Rats

被引：0
|
作者：
T. L. Karaseva
E. B. Likhota
Ya. R. Krivenko
S. A. Semibrat’ev
V. I. Pavlovskii
机构：
[1] National Academy of Sciences of Ukraine,A. V. Bogatsky Physico
来源：
Pharmaceutical Chemistry Journal | 2017年 / 51卷
关键词：
synthesis; 1,2-dihydro-1,4-benzodiazepin-2-one; appetite; leptin;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of new 7-bromo-5-(2′-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine derivatives (II-VIII) were synthesized. The series of synthesized compounds included those that had a substantial effect on appetite in rats, exhibiting both orexigenic and anorexigenic effects at low doses (2.07 – 2.21 μM). Compound VI had anorexigenic activity comparable with that of the hormone leptin, which reduces the appetite and food intake. Co-administration of leptin and III, which exhibited a pronounced orexigenic effect, reduced appetite by 73%.
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页码：258 / 261
页数：3
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