Novel Mononuclear Zinc(II) Complex with Niacin: Crystal Structure, DNA/Protein Interaction, and Cytotoxicity Studies

被引：0

作者：

C. Zhao

L. Huang

Q. Wang

机构：

[1] Yancheng Teachers’ University,School of Pharmacy

[2] Yancheng City No.1 People’s Hospital,Department of Thoracic Surgery

来源：

Journal of Applied Spectroscopy | 2022年 / 88卷

关键词：

zinc(II) complexes; crystal structure; DNA binding; protein binding; anticancer activity; circular dichroism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new mononuclear zinc(II) complex Zn(niacin)2(H2O)4 (1) is synthesized. The interaction of 1 with calf thymus-DNA is investigated by UV-Vis and fluorescence spectrometry, and the apparent binding constant (Kapp) value is established as 4.6 × 105 M–1. It is found that the quenching mechanism between bovine serum albumin and 1 might be a static quenching procedure with one binding site. Further, the anticancer activity of the complex on three human tumor cells lines (HT29, HepG2, and MCF-7) is studied. The IC50 values of 1 on HT29, HepG2, and MCF-7 are 114.1 ± 8, 146.7 ± 14, and 319.2 ± 13 μM, respectively.

引用

页码：1247 / 1256

页数：9

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