A paradox of immunodeficiency and inflammation in human aging: Lessons learned from apoptosis

被引：7

作者：

Gupta S. ^{[1
]}

Agrawal A. ^{[1
]}

Agrawal S. ^{[1
]}

Su H. ^{[1
]}

Gollapudi S. ^{[1
]}

机构：

[1] Laboratories of Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine

来源：

Immunity & Ageing | / 3卷 / 1期

关键词：

Apoptotic Cell; Amyotrophic Lateral Sclerosis; Aged Subject; Death Receptor; Aged Human;

D O I：

10.1186/1742-4933-3-5

中图分类号：

学科分类号：

摘要：

Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed. © 2006 Gupta et al; licensee BioMed Central Ltd.

引用

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