REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

被引：0
|
作者：
Alma Rodenas-Ruano
Andrés E Chávez
Maria J Cossio
Pablo E Castillo
R Suzanne Zukin
机构：
[1] Albert Einstein College of Medicine,Dominick P. Purpura Department of Neuroscience
来源：
Nature Neuroscience | 2012年 / 15卷
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摘要：
Expression of GluN2 subunit of NMDA receptor (NMDAR) in rodents is developmentally regulated such that GluN2B expression is high during early postnatal period but is replaced by GluN2A in adulthood, thus conferring different NMDAR channel properties and kinetics. This study identifies a molecular mechanism for GluN2A/B switch that is mediated by the transcriptional repressor REST. This process is also shown to be affected by postnatal stress induced by maternal deprivation, leading to long-lasting effects on NMDAR-subunit composition in the hippocampus.
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页码：1382 / 1390
页数：8
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