Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene

被引：0
|
作者：
F. Kishi
S. Fujishima
M. Tabuchi
机构：
[1] Center for Gene Research,
[2] Yamaguchi University,undefined
[3] 1-1-1 Minami-Kogushi,undefined
[4] Ube,undefined
[5] Yamaguchi 755-8505,undefined
[6] Japan Tel. +81-836-22-2183; Fax +81-836-22-2185 e-mail: fkishi-ygc@umin.ac.jp,undefined
[7] Department of Emergency and Critical Care Medicine,undefined
[8] School of Medicine,undefined
[9] Keio University,undefined
[10] Tokyo,undefined
[11] Japan,undefined
来源：
Journal of Human Genetics | 1999年 / 44卷
关键词：
Key wordsNRAMP2; DMT1; Dinucleotide repeat; Iron transport;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.
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页码：425 / 427
页数：2
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