A preliminary study of new imaging agents on inflammatory lesions

The purpose of the investigation was to evaluate the feasibility of imaging inflammatory lesions with five small molecular weight complexes of 99mTc. The labeling yields of D-glucaric acid (D-Gca), citric acid (Cit), DL-malic acid (DL-Mal), L-malic acid (L-Mal) and tartaric acid (Tar) were all more than 90%. The percentage uptake/g tissue of them and 99mTc-pertechnetate (P) in mice with turpentine-induced abscesses and abscess/muscle (A/M), blood (A/B), liver (A/L), kidney (A/K) concentration ratios were calculated. The maximum A/M ratios were 4.02±0.21 (Cit. 3h), 4.30±0.77 (D-Gca, 3h), 4.04±0.21 (DL-Mal, 6h), 3.50±0.23 (L-Mal, 1h), 3.20±0.17 (Tar, 1h) and 3.23±0.41 (P, 1h) respectively. The scintigram was obtained in a rabbit with turpentine-induced abscess after 99mTc-D-Gca i.v. injection. Results demonstrated they all can accumulate in inflammatory lesions. Of them, 99mTc-D-Gca is probably a potential imaging agent on inflammatory lesions.