Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

被引：0

作者：

Yingdi Wang

Masanori Nakayama

Mara E. Pitulescu

Tim S. Schmidt

Magdalena L. Bochenek

Akira Sakakibara

Susanne Adams

Alice Davy

Urban Deutsch

Urs Lüthi

Alcide Barberis

Laura E. Benjamin

Taija Mäkinen

Catherine D. Nobes

Ralf H. Adams

机构：

[1] Vascular Development Laboratory,Department of Tissue Morphogenesis

[2] Cancer Research UK London Research Institute,Departments of Physiology & Pharmacology and Biochemistry

[3] Max-Planck-Institute for Molecular Biomedicine,undefined

[4] and Faculty of Medicine,undefined

[5] University of Münster,undefined

[6] School of Medical Sciences,undefined

[7] University of Bristol,undefined

[8] Centre de Biologie du Développement,undefined

[9] Université de Toulouse,undefined

[10] CNRS,undefined

[11] CBD UMR 5547,undefined

[12] F-31062 Toulouse cedex 9,undefined

[13] France ,undefined

[14] Theodor Kocher Institute,undefined

[15] University of Berne,undefined

[16] Oncalis AG,undefined

[17] Beth Israel Deaconess Medical Center,undefined

[18] Boston,undefined

[19] Massachusetts 02215-5501,undefined

[20] USA ,undefined

[21] Cancer Research UK London Research Institute,undefined

[22] Lymphatic Development Laboratory,undefined

来源：

Nature | 2010年 / 465卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Ephrin-B ligands are well known as axon guidance molecules. Ephrin-B2 is also known to play a role in angiogenic remodelling. Two studies now show that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating VEGFR internalization and signalling. The finding suggests that blocking ephrin-B2 signalling may be an alternative approach to blocking VEGFR function in angiogenesis.

引用

页码：483 / 486

页数：3

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