VEGF and ephrin-B2: a bloody duo

被引：21
|
作者：
Germain, Stephane [1 ]
Eichmann, Anne [1 ]
机构：
[1] Coll France, INSERM, U833, F-75231 Paris, France
来源：
NATURE MEDICINE | 2010年 / 16卷 / 07期
关键词：
CARDIOVASCULAR DEVELOPMENT; ANGIOGENESIS; MORPHOGENESIS;
D O I：
10.1038/nm0710-752
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ephrin-B2 is required for the formation of blood and lymphatic vessels, but the mechanism has been enigmatic. Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors-thereby regulating VEGF-induced angiogenesis in normal and pathological conditions.
引用
收藏
页码：752 / 754
页数：4
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