First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits

被引:0
|
作者
Gregório Miguel Ferreira de Camargo
Diercles Francisco Cardoso
Fernanda Maria Monsalves Gil
Patrícia Dias da Silva Fonseca
Larissa Zetouni
Camila Urbano Braz
Ana Claudia de Freitas
Fábio Ricardo Pablos de Souza
Rusbel Raul Aspilcueta-Borquis
Fernando Baldi
Lucia Galvão de Albuquerque
Luciana Correia de Almeida Regitano
Humberto Tonhati
机构
[1] São Paulo State University,
[2] São Paulo University,undefined
[3] Brazilian Agricultural Research Corporation (Embrapa),undefined
来源
Molecular Biology Reports | 2012年 / 39卷
关键词
Molecular markers; Nellore; SNP; Reproductive traits; Chromosome 29;
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摘要
Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3′UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %.
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页码:10105 / 10109
页数:4
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