Subclonal diversification of primary breast cancer revealed by multiregion sequencing

被引：0

作者：

Lucy R Yates

Moritz Gerstung

Stian Knappskog

Christine Desmedt

Gunes Gundem

Peter Van Loo

Turid Aas

Ludmil B Alexandrov

Denis Larsimont

Helen Davies

Yilong Li

Young Seok Ju

Manasa Ramakrishna

Hans Kristian Haugland

Peer Kaare Lilleng

Serena Nik-Zainal

Stuart McLaren

Adam Butler

Sancha Martin

Dominic Glodzik

Andrew Menzies

Keiran Raine

Jonathan Hinton

David Jones

Laura J Mudie

Bing Jiang

Delphine Vincent

April Greene-Colozzi

Pierre-Yves Adnet

Aquila Fatima

Marion Maetens

Michail Ignatiadis

Michael R Stratton

Christos Sotiriou

Andrea L Richardson

Per Eystein Lønning

David C Wedge

Peter J Campbell

机构：

[1] Cancer Genome Project,Department of Oncology

[2] Wellcome Trust Sanger Institute,Department of Clinical Science

[3] The University of Cambridge,Department of Oncology

[4] Section of Oncology,Department of Human Genetics

[5] University of Bergen,Department of Surgery

[6] Haukeland University Hospital,Theoretical Division

[7] Breast Cancer Translational Research Laboratory,Department of Pathology

[8] Institut Jules Bordet,Department of Clinical Medicine

[9] Université Libre de Bruxelles,undefined

[10] University of Leuven,undefined

[11] Haukeland University Hospital,undefined

[12] Los Alamos National Laboratory,undefined

[13] Haukeland University Hospital,undefined

[14] The Gade Laboratory for Pathology,undefined

[15] University of Bergen,undefined

[16] Dana-Farber Cancer Institute,undefined

[17] Brigham and Women's Hospital,undefined

[18] Harvard Medical School,undefined

来源：

Nature Medicine | 2015年 / 21卷

关键词：

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中图分类号：

学科分类号：

摘要：

Whole-genome and targeted sequencing of multiple sections of each of 50 tumors reveals varying degrees of subclonal diversification and genomic heterogeneity.

引用

页码：751 / 759

页数：8

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