The lock-washer: a reconciliation of the RIG-I activation models

被引：0

作者：

Shu Zhu

Ruaidhri Jackson

Richard A Flavell

机构：

[1] Yale University,Department of Immunobiology

[2] Howard Hughes Medical Institute,undefined

[3] Yale University,undefined

来源：

Cell Research | 2014年 / 24卷

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D O I：

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摘要：

RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.

引用

页码：645 / 646

页数：1

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