The lock-washer: a reconciliation of the RIG-I activation models

被引：0
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作者：
Shu Zhu
Ruaidhri Jackson
Richard A Flavell
机构：
[1] Yale University,Department of Immunobiology
[2] Howard Hughes Medical Institute,undefined
[3] Yale University,undefined
来源：
Cell Research | 2014年 / 24卷
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摘要：
RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.
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页码：645 / 646
页数：1
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