Molecular and cellular mechanisms of CLL: novel therapeutic approaches

被引：0
|
作者：
Lisa Pleyer
Alexander Egle
Tanja Nicole Hartmann
Richard Greil
机构：
[1] Medical Oncology,Laboratory for Immunological and Molecular Cancer Research and IIIrd Medical Department with Hematology
[2] Hemostaseology,undefined
[3] Rheumatology and Infectiology,undefined
[4] Paracelsus Medical University Salzburg,undefined
[5] Laboratory for Immunological and Molecular Cancer Research,undefined
来源：
Nature Reviews Clinical Oncology | 2009年 / 6卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
The mainstay of therapy of chronic lymphocytic leukemia (CLL) is cytotoxic chemotherapy; however, CLL is still an incurable disease with resistance to therapy developing in a majority of patients. This Review summarizes the progress made in understanding the biological basis of CLL pathogenesis and other aspects of CLL biology, and describes novel treatment strategies that have also been exploited in current clinical trials.
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页码：405 / 418
页数：13
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