Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis

被引：0
|
作者：
Vincenzo Chiarugi
Mario Del Rosso
Lucia Magnelli
机构：
[1] University of Firenze,Operative Unit of Molecular Biology of Azienda Ospedaliera Careggi, Department of Experminetal Pathology and Oncology
来源：
Molecular Biotechnology | 2002年 / 22卷
关键词：
Brn-3a; Bcl-2; p53; VEGF;
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学科分类号：
摘要：
Brn-3a, a member of the POU gene family (so-called because of the similarity with the group of transcription factors Pit, Oct, and Unc), was found in neuronal cells engaged in the transcription activity of the p1 and p2 promoters of the most powerful antiapoptotic gene, namely, Bcl-2. The alternative splicing of Brn-3a mRNA produces two molecular forms: a longer, Bcl-2 transactivating form, and a shorter inactive form, lacking 84 AA in the aminoterminus. In neuronal cells, following Brn-3a gene transfection and superexpression, an increase of 30 fold of the Bcl-2 protein occurs, leading to apoptosis protection.
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页码：123 / 127
页数：4
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