The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells

被引：0
|
作者：
Jai Parkash
Zhenmin Lei
C. V. Rao
机构：
[1] Robert Stempel College of Public Health and Social Work,Department of Environmental and Occupational Health
[2] Florida International University,Department of Obstetrics and Gynecology
[3] Keiser University,Department of Cellular Biology and Pharmacology
[4] University of Louisville Medical Center,undefined
[5] Herbert Wertheim College of Medicine,undefined
[6] Florida International University,undefined
来源：
Reproductive Sciences | 2015年 / 22卷
关键词：
hCG/LH receptors; β-cells of pancreas; colocalization; insulin release; glucose;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the possible presence of functional human chorionic gonadotropin (hCG)/luteinizing hormone (LH) receptors in β-cells of pancreas, using a combination of techniques on hCG/LH receptor knockout mice, immortalized rat insulinoma cells, and human pancreatic islets. The results showed the presence of receptors and their activation resulted in a dose-dependent increase in glucose-induced release of insulin. These findings place hCG and LH among the regulators of insulin release with potential implications for insulin-level changes during the periods of altered hCG and LH secretion.
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页码：1000 / 1007
页数：7
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