Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

被引：0
|
作者：
Xiu Mei Ma
Kang Geng
Betty Yuen-Kwan Law
Peng Wang
Yue Li Pu
Qing Chen
Hui Wen Xu
Xiao Zhen Tan
Zong Zhe Jiang
Yong Xu
机构：
[1] Macau University of Science and Technology,Faculty of Chinese Medicine
[2] State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology),Department of Endocrinology and Metabolism
[3] The Affiliated Hospital of Southwest Medical University,Department of Plastic and Burn Surgery
[4] Metabolic Vascular Diseases Key Laboratory of Sichuan Province,undefined
[5] Sichuan Clinical Research Center for Nephropathy,undefined
[6] The Affiliated Hospital of Southwest Medical University,undefined
来源：
Cell Biology and Toxicology | 2023年 / 39卷
关键词：
Lipotoxicity; mtDNA release; cGAS-STING; Diabetic cardiomyopathy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mitochondria-derived cytosolic DNA acts as a critical linker between hyperlipidemia-induced mitochondrial dysfunction and pathogenesis of DCM.cGAS-STING pathway mediates the lipotoxicity-induced myocardial dysfunction through sensing released cytosolic mtDNA.STING was identified as a new potential therapeutic target for the treatment of DCM.
引用
收藏
页码：277 / 299
页数：22
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