Fundamentally low reproducibility in molecular genetic cancer research

被引：0
|
作者：
I. V. Alekseenko
V. V. Pleshkan
G. S. Monastyrskaya
A. I. Kuzmich
E. V. Snezhkov
D. A. Didych
E. D. Sverdlov
机构：
[1] Russian Academy of Sciences,Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
来源：
Russian Journal of Genetics | 2016年 / 52卷
关键词：
cancer; pancreas; complex system; irreproducibility; cancer criteria; heterogeneity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.
引用
收藏
页码：650 / 663
页数：13
相关论文
共 50 条
  • [31] Reproducibility of Research in Biophysics
    Loew, Les
    Beckett, Dorothy
    Egelman, Edward H.
    Scarlata, Suzanne
    BIOPHYSICAL JOURNAL, 2015, 108 (07) : E01 - E01
  • [32] Reproducibility in ecological research
    Huang, Xiaolei
    SCIENCE, 2014, 346 (6215) : 1307 - 1307
  • [33] Research Culture and Reproducibility
    Munafo, Marcus R.
    Chambers, Christopher D.
    Collins, Alexandra M.
    Fortunato, Laura
    Macleod, Malcolm R.
    TRENDS IN COGNITIVE SCIENCES, 2020, 24 (02) : 91 - 93
  • [34] Reproducibility in Chemical Research
    Bergman, Robert G. (rbergman@berkeley.edu), 1600, Wiley-VCH Verlag (55):
  • [35] Genetic and molecular changes in ovarian cancer
    Hollis, Robert L.
    Gourley, Charlie
    CANCER BIOLOGY & MEDICINE, 2016, 13 (02) : 236 - 247
  • [36] WRESTLING WITH REPRODUCIBILITY IN RESEARCH
    Dove, Patricia M.
    ELEMENTS, 2014, 10 (05) : 323 - 324
  • [37] A molecular genetic view of cancer progression
    Kallioniemi, OP
    EUROPEAN JOURNAL OF CANCER, 1995, 31A : 444 - 444
  • [38] Molecular genetic phenotypes of colorectal cancer
    Tatiana, K.
    ANNALS OF ONCOLOGY, 2024, 35 : S69 - S69
  • [39] Genetic and molecular changes in ovarian cancer
    Robert L Hollis
    Charlie Gourley
    Cancer Biology & Medicine, 2016, 13 (02) : 236 - 247
  • [40] Molecular and genetic pathways in penile cancer
    Kayes, Oliver
    Ahmed, Hashim U.
    Arya, Manit
    Minhas, Suks
    LANCET ONCOLOGY, 2007, 8 (05): : 420 - 429
12345