Fundamentally low reproducibility in molecular genetic cancer research

被引：0
|
作者：
I. V. Alekseenko
V. V. Pleshkan
G. S. Monastyrskaya
A. I. Kuzmich
E. V. Snezhkov
D. A. Didych
E. D. Sverdlov
机构：
[1] Russian Academy of Sciences,Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
来源：
Russian Journal of Genetics | 2016年 / 52卷
关键词：
cancer; pancreas; complex system; irreproducibility; cancer criteria; heterogeneity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The review discusses the causes of multiple failures in cancer treatment, which might primarily result from the excessive variability of cancer genomes. They are capable of changing their spatial and temporal architecture during tumor development. The key reasons of irreproducibility of biomedical data and the presumable means for improvement of therapeutic results aiming at targeting the most stable tumor traits are suggested.
引用
收藏
页码：650 / 663
页数：13
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